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A neuropathological examination was performed on a patient with parkinsonism induced by prolonged exposure to a mixture of aliphatic hydrocarbons,mainly n-hexane and halogenated compounds.The patient developed a rapid course disease that progressed even after withdrawal from the toxic exposure.Pathological examination and immunohistochemical analysis of the brain revealed severe and widespread dopaminergic neuronal loss,associated with severe gliosis in the substantia nigra and almost complete loss of tyrosine hydroxylase immunostaining in the striatum.No Lewy bodies were detected.Neuronal loss was also observed in the periaquaductal gray matter,locus ceruleus,and pedunculopontine nucleus. These changes,combined with the moderate anemia due to marrow suppression, and the mild axonal neuropathy observed in vivo are suggestive of a hydrocarbon toxic insult. |
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drug induced neurologic disorders
hexane
movement disorder,drug induced
neuropathology
neuropathology,brain
neurotoxin
Parkinson disease
Parkinson disease,drug induced
solvent
toxins,nervous system
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